Author/Authors :
Stéphane Rodier، نويسنده , , Yvan Le Huérou، نويسنده , , Brigitte Renoux، نويسنده , , Julien Doyon، نويسنده , , Pierre Renard، نويسنده , , Alain Pierré، نويسنده , , Jean-Pierre Gesson، نويسنده , , René Grée*، نويسنده ,
Abstract :
A set of 16 new simplified analogues of acetogenins has been designed based on: (i) the replacement of the bis THF moiety of these natural products by an ethylene glycol bis ether unit; (ii) the introduction of different lipophilic side chains (alkyl, aryl, dialkylamino, O-cholesteryl); (iii) the presence of the same terminal isolactone. In vitro cytotoxic activity against L1210 leukemia is reported.
