Title of article
N-(Indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the α1 subunit
Author/Authors
Ian Collins، نويسنده , , William B. Davey، نويسنده , , Michael Rowley، نويسنده , , Kathleen Quirk، نويسنده , , Frances A. Bromidge، نويسنده , , Ruth M. McKernan، نويسنده , , Sally-Anne Thompson، نويسنده , , Keith A. Wafford، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1381
To page
1384
Abstract
A new class of N-(indol-3-ylglyoxylyl)piperidines are high affinity agonists at the benzodiazepine binding site of human GABA-A receptor ion-channels, with modest selectivity for receptors containing the α1 subunit over α2 and α3. All three receptor subtypes discriminate substantially between the two enantiomers of the chiral ligand 10.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790876
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