Author/Authors :
Ian Collins، نويسنده , , William B. Davey، نويسنده , , Michael Rowley، نويسنده , , Kathleen Quirk، نويسنده , , Frances A. Bromidge، نويسنده , , Ruth M. McKernan، نويسنده , , Sally-Anne Thompson، نويسنده , , Keith A. Wafford، نويسنده ,
Abstract :
A new class of N-(indol-3-ylglyoxylyl)piperidines are high affinity agonists at the benzodiazepine binding site of human GABA-A receptor ion-channels, with modest selectivity for receptors containing the α1 subunit over α2 and α3. All three receptor subtypes discriminate substantially between the two enantiomers of the chiral ligand 10.
