Author/Authors :
Pier Giovanni Baraldi، نويسنده , , Romeo Romagnoli، نويسنده , , Adriano Duatti، نويسنده , , Cristina Bolzati، نويسنده , , Adriano Piffanelli، نويسنده , , Nicoletta Bianchi، نويسنده , , Carlo Mischiati، نويسنده , , University of Perugia
Roberto Gambari، نويسنده ,
Abstract :
The synthesis of a hybrid constituted by distamycin A and cysteine labeled with the γ-emitting radionuclide 99mTc to afford the conjugate complex 5 is reported. This new radiopharmaceutical is of potential interest as tumor imaging agent in diagnostic nuclear medicine. The preparation of the hybrid distamycin A-cysteine 4 has been achieved by coupling deformyldistamycin A and Boc-Dmt-OH. Compound 4 was then successfully labeled with 99mTc by reaction with the novel, high-electrophilic, metal-containing fragment [99mTc(N)(PP)]2+ (PP=diphosphine ligand) yielding the 1:1 complex 5.
