Title of article
Synthesis and structure–activity relationships of novel fungal chitin synthase inhibitors
Author/Authors
Kazunao Masubuchi، نويسنده , , Mikio Taniguchi، نويسنده , , Isao Umeda، نويسنده , , Kazuo Hattori، نويسنده , , Hitomi Suda، نويسنده , , Yasunori Kohchi، نويسنده , , Yoshiaki Isshiki، نويسنده , , Toshiya Sakai، نويسنده , , Masami Kohchi، نويسنده , , Michio Shirai، نويسنده , , Hisafumi Okabe، نويسنده , , Masayuki Sudoh، نويسنده , , Toshikazu Yamazaki، نويسنده , , Nobuo Shimma، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1459
To page
1462
Abstract
A novel Candida albicans chitin synthase 1 (CaChs1) inhibitor, RO-41-0986 (1) was discovered by random screening. Systematic modification led to the identification of a highly potent CaChs1 inhibitor, RO-09-3024 (2), having strong antifungal activity against Candida spp. in vitro.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790896
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