Title of article
Difluoroketones as inhibitors of matrix metalloprotease-13
Author/Authors
Lawrence A. Reiter، نويسنده , , Gary J. Martinelli، نويسنده , , Lisa A. Reeves، نويسنده , , Peter G. Mitchell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1581
To page
1584
Abstract
Substrate-like difluoroketones have been prepared as potential inhibitors of MMP-13. Weak inhibition was seen with the key target 2. This and the more potent activity of intermediate 7b illustrates that hydrated ketones can be used to inhibit MMP-13 and perhaps other members of this class of enzymes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790926
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