Author/Authors :
Moorthy S. S. Palanki، نويسنده , , Paul E. Erdman، نويسنده , , Anthony M. Manning، نويسنده , , Arnold Ow، نويسنده , , Lynn J. Ransone، نويسنده , , Cheryl Spooner، نويسنده , , Carla Suto، نويسنده , , Mark Suto، نويسنده ,
Abstract :
In an effort to identify novel inhibitors of AP-1 and NF-κB mediated transcriptional activation, several analogues of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carboxylate (1) were synthesized and tested in two in vitro assays. The 2-(2′-thienyl) substituted compound (11) was identified as the most potent in this series.
