Title of article
Novel inhibitors of AP-1 and NF-κB mediated gene expression: structure–activity relationship studies of ethyl 4-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carboxylate
Author/Authors
Moorthy S. S. Palanki، نويسنده , , Paul E. Erdman، نويسنده , , Anthony M. Manning، نويسنده , , Arnold Ow، نويسنده , , Lynn J. Ransone، نويسنده , , Cheryl Spooner، نويسنده , , Carla Suto، نويسنده , , Mark Suto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1645
To page
1648
Abstract
In an effort to identify novel inhibitors of AP-1 and NF-κB mediated transcriptional activation, several analogues of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carboxylate (1) were synthesized and tested in two in vitro assays. The 2-(2′-thienyl) substituted compound (11) was identified as the most potent in this series.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790942
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