Efficient synthesis of 8-Oxo-dGTP: A mutagenic nucleotide

An efficient synthesis of mutagenic and oxidative DNA damage product, 8-oxo-dGTP (Figure 1 and Scheme 2) has been achieved in high yield, along with a serendipitous generation of 8-dimsyl-dG ( 2). In combination with dPTP ( 5), 8-oxo-dGTP ( Figure 1 and Scheme 2) can be formulated into a kit for investigating DNA random mutagenesis.