Title of article
Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents
Author/Authors
Jonathan R. Young، نويسنده , , Song X. Huang، نويسنده , , Irene Chen، نويسنده , , Thomas F. Walsh، نويسنده , , Robert J. DeVita، نويسنده , , Matthew J. WyvrattJr.، نويسنده , , Mark T. Goulet، نويسنده , , Ning Ren، نويسنده , , Jane Lo، نويسنده , , Yi Tien Yang، نويسنده , , Joel B. Yudkovitz، نويسنده , , Kang Cheng، نويسنده , , Roy G. Smith، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
1723
To page
1727
Abstract
A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790960
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