Author/Authors :
Mona Patel، نويسنده , , Robert J. McHughJr.، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , Susan Erickson-Viitanen، نويسنده , , George L. Trainor، نويسنده , , James D. Rodgers III، نويسنده ,
Abstract :
A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N-allyl (6b and 6f), N-cyclopropylmethyl (6a, 6g, 6h, and 6k) and N-carboalkoxy (6m–6y) substituted compounds displayed activity comparable or better than Efavirenz and GW420867X.
