Title of article :
Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors
Author/Authors :
Joan Bosch، نويسنده , , Tomàs Roca، نويسنده , , Juan-Lorenzo Catena، نويسنده , , Oriol Llorens، نويسنده , , Juan-Jes?s Pérez، نويسنده , , Carmen Lagunas، نويسنده , , Andrés G. Fern?ndez، نويسنده , , Ignasi Miquel، نويسنده , , Ana Fern?ndez-Serrat، نويسنده , , Carles Farrerons، نويسنده ,
Abstract :
The synthesis and structure–activity relationships (SAR) of a series of novel selective COX-2 inhibitors are reported. The results show that some of the 1,3,4-triaryl-3-pyrrolin-2-ones 1 are more potent as COX-2 inhibitors than celecoxib, and that lactam 1d has the same selectivity.
