Synthesis of aminophosphonate haptens for an aminoacylation reaction between methyl glucoside and a β-alanyl ester

Two 2-aminophosphonate haptens derived from methyl α- -glucopyranoside were synthesized to mimic the transition-state of a transesterification reaction between methyl α- -glucopyranoside and 4-nitrophenylester of tert-BOC-β-alanine. Two sets of monoclonal antibodies were generated against these haptens.