Title of article
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists
Author/Authors
S. Richard Baker، نويسنده , , David Bleakman، نويسنده , , Jesus Ezquerra، نويسنده , , Barbara A. Ballyk، نويسنده , , Michele Deverill، نويسنده , , Ken Ho، نويسنده , , Rajender K. Kamboj، نويسنده , , Ivan Collado، نويسنده , , M del Carmen DomInguez، نويسنده , , Ana Escribano، نويسنده , , Ana I. Mateo، نويسنده , , Concepcion Pedregal، نويسنده , , Almudena Rubio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1807
To page
1810
Abstract
Twenty-four 4-alkylidene glutamic acids were synthesised and tested as potential subtype selective GluR5 and 6 ligands. It was found that a critical size of alkylidene group gave potent and selective GluR5 receptor agonists. LY339624 had Kis of 0.0326 and >100 μM on GluR5 and 6 receptors, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790981
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