Title of article :
Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines
Author/Authors :
Stephen J. Gregson، نويسنده , , Philip W. Howard، نويسنده , , Kathryn E. Corcoran، نويسنده , , Simona Barcella، نويسنده , , Maqsood M. Yasin، نويسنده , , Abigail A. Hurst، نويسنده , , Terence C. Jenkins، نويسنده , , Lloyd R. Kelland، نويسنده , , David E. Thurston، نويسنده ,
Abstract :
A series of novel C2-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) has been synthesised via a versatile pro-C2 ketone precursor. C2-exo-unsaturation enhances both DNA-binding reactivity and in vitro cytotoxic potency.
