Title of article
Discovery and synthesis of a potent sulfonamide ETB selective antagonist
Author/Authors
Yasuhiko Kanda، نويسنده , , and Tadashi Takahashi، نويسنده , , Yoshitaka Araki، نويسنده , , Toshiro Konoike*، نويسنده , , Shin-ichi Mihara، نويسنده , , Masafumi Fujimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1875
To page
1878
Abstract
The synthesis and structure–activity relationships of a series of sulfonamide endothelin antagonists are described. In the course of our modification studies, we discovered ETB selective antagonists. The most potent compound 15f displays IC50 values of 1.7 μM and 0.002 μM to ETA and ETB receptors, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790996
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