Title of article :
Synthesis and preliminary biological evaluation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones, a new class of calcium entry blockers
Author/Authors :
Fedele Manna، نويسنده , , Franco Chimenti، نويسنده , , Adriana Bolasco، نويسنده , , Bruna Bizzarri، نويسنده , , Maurizio Botta، نويسنده , , Andrea Tafi، نويسنده , , Amelia Filippelli، نويسنده , , Settimio Rossi، نويسنده ,
Abstract :
The preparation of 3-cyano-4,6-diaryl-pyridin-2(1H)-ones 4a–h, calcium entry blockers related to diltiazem, is described starting from 1,3-diaryl-2-propen-1-ones 5. On preliminary pharmacological tests all compounds are active and some of them show calcium antagonistic activity superior or comparable to diltiazem.
