DNA Triple Helix Stabilization by Aminoglycoside Antibiotics

The stabilization of the poly(dA)√2poly(dT) triple helix by neomycin is reported. Preliminary results indicate that neomycin stabilizes DNA triple helices and the double helical structures composed of poly(dA)√poly(dT) are virtually unaffected. This is the first report of the interaction of aminoglycoside antibiotics with DNA triple helices.