Title of article
Targeting the dimerization interface for irreversible inhibition of HIV-1 protease
Author/Authors
Reena Zutshi، نويسنده , , Jean Chmielewski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
1901
To page
1903
Abstract
A novel strategy was used to irreversibly inhibit HIV-1 protease. The inhibitor was designed to form a disulfide bond with Cys95, present at the dimerization interface of HIV-1 protease. The inhibitor was shown to be active against HIV-1 protease with Kinact=3.7 μM and Vinact=0.012 min−1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791002
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