Author/Authors :
Graham B. Jones، نويسنده , , Miguel O. Mitchell، نويسنده , , James S. Weinberg، نويسنده , , Anthony V. DʹAmico، نويسنده , , Glenn J. Bubley، نويسنده ,
Abstract :
A prodrug conjugate designed to undergo activation by enzymatic prostate specific antigen has been synthesized. The prodrug system undergoes activation with PSA or α-chymotrypsin, and shows selective cytotoxicity in a PSA secreting cell line.