Title of article :
N1-Arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor
Author/Authors :
Philippe Dauban، نويسنده , , Sandrine Ferry، نويسنده , , Marie-Hélène Fauré، نويسنده , , Martial Ruat، نويسنده , , Robert H. Dodd، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
The synthesis and calcimimetic properties of N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines are described. The most active compound of the series (3n, used at 10 μM) produced 97±11% of the maximal stimulation of [3H]IP production obtained by 10 mM Ca2+ in CHO cells expressing the calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
