Title of article
A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline
Author/Authors
Vittorio Caprio، نويسنده , , Berengere Guyen، نويسنده , , Yaw Opoku-Boahen، نويسنده , , John Mann، نويسنده , , Sharon M. Gowan، نويسنده , , Lloyd M. Kelland، نويسنده , , Martin A. Read، نويسنده , , Stephen Neidle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2063
To page
2066
Abstract
The bis-dimethylaminoethyl derivative of quindoline (10H-indolo[3,2-b]quinoline), an alkaloid from the West African shrub Cryptolepis sanguinolenta, has been synthesised. This has been shown to have modest cytotoxicity, as well as inhibitory activity against the telomerase enzyme. It is hypothesised that the latter activity is due to stabilisation of an intermediate guanine-quadruplex complex, in accordance with computer modelling.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791040
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