Title of article
A QSAR study investigating the effect of -alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T
Author/Authors
Michael H. Knaggs، نويسنده , , Christopher McGuigan، نويسنده , , Sarah A. Harris، نويسنده , , Parissa Heshmati، نويسنده , , Dominique Cahard، نويسنده , , Ian H. Gilbert، نويسنده , , Jan Balzarini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2075
To page
2078
Abstract
A QSAR study, involving the use of calculated physical properties (TSAR™), and the use of a neural network approach (TSAR™), has been performed concerning the anti-HIV activity and cytotoxic effects of a series of d4T phosphoramidate derivatives with varying -alanine esters. Models were obtained which allow reliable predictions for the anti-HIV activity, and cytotoxicity, of these derivatives.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791043
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