Title of article
Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT
Author/Authors
Marina J. Sagnou، نويسنده , , Philip W. Howard، نويسنده , , Stephen J. Gregson، نويسنده , , Ebun Eno-Amooquaye، نويسنده , , Philip J. Burke، نويسنده , , David E. Thurston، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2083
To page
2086
Abstract
Three N10-(4-nitrobenzyl)carbamate-protected PBD prodrugs (9a, 9b and 15) have been synthesized and evaluated for potential use in nitroreductase-based ADEPT and GDEPT therapies. An approximately 100-fold activation was observed for the DC-81 prodrug 9a.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791045
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