Author/Authors :
Marina J. Sagnou، نويسنده , , Philip W. Howard، نويسنده , , Stephen J. Gregson، نويسنده , , Ebun Eno-Amooquaye، نويسنده , , Philip J. Burke، نويسنده , , David E. Thurston، نويسنده ,
Abstract :
Three N10-(4-nitrobenzyl)carbamate-protected PBD prodrugs (9a, 9b and 15) have been synthesized and evaluated for potential use in nitroreductase-based ADEPT and GDEPT therapies. An approximately 100-fold activation was observed for the DC-81 prodrug 9a.
