Author/Authors :
Andrew F. Burchat، نويسنده , , David J. Calderwood، نويسنده , , Gavin C. Hirst، نويسنده , , Nicholas J. Holman، نويسنده , , David N. Johnston، نويسنده , , Rainer Munschauer، نويسنده , , Paul Rafferty، نويسنده , , Gerald B. Tometzki، نويسنده ,
Abstract :
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are novel, potent and selective inhibitors of lck in vitro. Exploration of C-6 position of the pyrrolo[2,3-d]pyrimidine and the terminal phenyl group structure–activity relationship (SAR) is detailed. Compound 1 is orally active in animal models.
