Title of article
Pyrrolo[2,3-d]pyrimidines Containing an Extended 5-Substituent as Potent and Selective Inhibitors of lck II
Author/Authors
Andrew F. Burchat، نويسنده , , David J. Calderwood، نويسنده , , Gavin C. Hirst، نويسنده , , Nicholas J. Holman، نويسنده , , David N. Johnston، نويسنده , , Rainer Munschauer، نويسنده , , Paul Rafferty، نويسنده , , Gerald B. Tometzki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2171
To page
2174
Abstract
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are novel, potent and selective inhibitors of lck in vitro. Exploration of C-6 position of the pyrrolo[2,3-d]pyrimidine and the terminal phenyl group structure–activity relationship (SAR) is detailed. Compound 1 is orally active in animal models.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791065
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