Novel antifungals based on 4-substituted imidazole: A combinatorial chemistry approach to lead discovery and optimization

A series of 4-substituted imidazole sulfonamides has been prepared by solid-phase chemistry. These compounds were found to have good in vitro antifungal activity and constitute the first examples of C-linked azoles with such activity. The most potent inhibitor (30) demonstrated inhibition of key Candida strains at an in vitro concentration of <100 nM and compared favorably with in vitro potency of itraconazole.