Title of article
Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists
Author/Authors
Yuguang Wang، نويسنده , , Samuel Chackalamannil، نويسنده , , Zhiyong Hu، نويسنده , , John W. Clader، نويسنده , , William Greenlee، نويسنده , , William Billard، نويسنده , , Herbert Binch III، نويسنده , , Gordon Crosby، نويسنده , , Vilma Ruperto، نويسنده , , Ruth A. Duffy، نويسنده , , Robert McQuade، نويسنده , , Jean E. Lachowicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2247
To page
2250
Abstract
Identification of a number of highly potent M2 receptor antagonists with >100-fold selectivity against the M1 and M3 receptor subtypes is described. In the rat microdialysis assay, this series of compounds showed pronounced enhancement of brain acetylcholine release after oral administration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791082
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