Title of article
Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases
Author/Authors
Philip D. Edwards، نويسنده , , Russell C. Mauger، نويسنده , , Kevin M. Cottrell، نويسنده , , Frank X. Morris، نويسنده , , Kara K. Pine، نويسنده , , Mark A. Sylvester، نويسنده , , Clay W. Scott، نويسنده , , Stephen T. Furlong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2291
To page
2294
Abstract
A method for the solid-phase synthesis of P1 arginine containing peptides via attachment of the arginine side-chain guanidine group is described. This procedure is applied to the preparation of a tetrapeptide, P1 arginine aminocoumarin PS-SCL. This library was validated by using it to determine the P4–P2 specificity for thrombin and comparing the results to the known thrombin subsite specificity. This is the first reported example of a PS-SCL library containing a P1 arginine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791093
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