Title of article :
Synthesis and NK1/NK2 receptor activity of substituted-4(Z)-(methoxyimino)pentyl-1-piperazines
Author/Authors :
Pauline C. Ting، نويسنده , , Joe F. Lee، نويسنده , , John C. Anthes، نويسنده , , Neng-Yang Shih، نويسنده , , John J. Piwinski، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
A series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-4(Z)-(methoxyimino)pentyl-1-piperazines was prepared and their affinity for the NK1 and NK2 receptors investigated. Compounds 7f, 10o, 10r, and 10s were found to be our most potent inhibitors.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
