Author/Authors :
Pascal Furet، نويسنده , , Giorgio Caravatti، نويسنده , , Alastair A. Denholm، نويسنده , , Alex Faessler، نويسنده , , Heinz Fretz، نويسنده , , Carlos Garcia-Echeverria، نويسنده , , Brigitte Gay، نويسنده , , Ed Irving، نويسنده , , Neil J. Press، نويسنده , , Joseph Rahuel، نويسنده , , Joseph Schoepfer، نويسنده , , Clive V. Walker، نويسنده ,
Abstract :
Based on X-ray crystal structure information, mono charged phosphinate isosteres of phosphotyrosine have been designed and incorporated in a short inhibitory peptide sequence of the Grb2-SH2 domain. The resulting compounds, by exploiting additional interactions, inhibit binding to the Grb2-SH2 domain as potently as the corresponding doubly charged (phosphonomethyl)phenylalanine analogue.
