Title of article :
1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors
Author/Authors :
Kumiko Takeuchi، نويسنده , , Jolie A. Bastian، نويسنده , , Donetta S. Gifford-Moore، نويسنده , , Richard W. Harper، نويسنده , , Shawn C. Miller، نويسنده , , Jeffrey T. Mullaney، نويسنده , , Daniel J. Sall، نويسنده , , Gerald F. Smith، نويسنده , , Minsheng Zhang، نويسنده , , Matthew J. Fisher، نويسنده ,
Abstract :
A novel series of 1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing an amine moiety was identified as thrombin inhibitors. An indole with basic diamine moieties (12a) was the most potent thrombin inhibitor in the series with Kass=197 × 106 L/mol.
