Title of article
Chemical modification of nodulisporic acid A: preliminary structure–activity relationships
Author/Authors
Peter T. Meinke، نويسنده , , Michelle B. Ayer، نويسنده , , Steven L. Colletti، نويسنده , , Chunshi Li، نويسنده , , Julie Lim، نويسنده , , Dong-Ok Kim، نويسنده , , Steve Salva، نويسنده , , Dennis M. Schmatz، نويسنده , , Thomas L. Shih، نويسنده , , Wesley L. Shoop، نويسنده , , Lynn M. Warmke، نويسنده , , Matthew J. Wyvratt Jr.، نويسنده , , Michelle Zakson-Aiken، نويسنده , , Michael H. Fisher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2371
To page
2374
Abstract
Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1 into ‘permissive’ and ‘nonpermissive’ regions and led to the discovery of new nodulisporamides with significantly improved flea efficacy.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791110
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