Title of article
Novel heterocycles as selective α1-adrenergic receptor antagonists
Author/Authors
Xiaobing Li، نويسنده , , Kathleen A. McCoy، نويسنده , , William V. Murray، نويسنده , , Linda Jolliffe، نويسنده , , Virginia Pulito، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
2375
To page
2377
Abstract
A novel series of aryl piperazine substituted heterocycles has been synthesized and identified as antagonists of the α1a-adrenergic receptor (α1a-AR), which has been implicated in benign prostatic hyperplasia (BPH). These compounds selectively inhibit binding to the α1a-AR with Kis as low as 2.1 nM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791111
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