Title of article
3α-(4-Substituted phenyl)nortropane-2β-carboxylic acid methyl esters show selective binding at the norepinephrine transporter
Author/Authors
Bruce E. Blough، نويسنده , , Christopher R. Holmquist، نويسنده , , Philip Abraham، نويسنده , , Michael J. Kuhar، نويسنده , , F. Ivy Carroll، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
2445
To page
2447
Abstract
A series of 3α-(4-substituted)nortropane-2β-carboxylic acid methyl esters was synthesized and evaluated for the ability to inhibit radioligand binding at the dopamine, serotonin, and norepinephrine transporters. 3α-(4-Methylphenyl)nortropane-2β-carboxylic acid methyl ester (4c) was found to be selective and highly potent for the norepinephrine transporter (NET) relative to the dopamine and serotonin transporters.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791126
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