Title of article
N-[1-(2-Phenylethyl)pyrrolidin-3-yl]-1-adamantanecarboxamides as novel 5-HT2 receptor antagonists
Author/Authors
Masakazu Fujio، نويسنده , , Takanobu Kuroita، نويسنده , , Yoko Sakai، نويسنده , , Haruto Nakagawa، نويسنده , , Yasuhiro Matsumoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
2457
To page
2461
Abstract
A series of 1-adamantanecarboxamides was synthesized and examined for their potency as a selective 5-HT2 receptor antagonist. We found (S)-N-{1-[2-(4-fluorophenyl)ethyl]pyrrolidin-3-yl}-1-adamantanecarboxamide hydrochloride hydrate (10-(S), Y-39241) to have a high affinity and selectivity for 5-HT2 receptors, and this potent anti-platelet effect of Y-39241 was confirmed both in vitro and in vivo
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791129
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