• Title of article

    Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A

  • Author/Authors

    V. Rajendran and B. H. Chen، نويسنده , , K. R. C. Prakash، نويسنده , , Haresh S. Ved، نويسنده , , Ashima Saxena، نويسنده , , Bhupendra P. Doctor، نويسنده , , Alan P. Kozikowski، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2000
  • Pages
    3
  • From page
    2467
  • To page
    2469
  • Abstract
    (±)-10,10-Dimethylhuperzine A (2, DMHA) has been synthesized, and its enantiomers have been separated using chiral HPLC. (−)-DMHA inhibits AChE with a Ki value approaching that of (−)-huperzine A, whereas (+)-DMHA shows no AChE inhibitory activity. On the other hand, both enantiomers are equally potent against glutamate-induced neurotoxicity when tested in neurons.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2000
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    791131

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791131