• Title of article

    Synthesis of a heterocyclic aza-enediyne and its DNA-cleavage properties

  • Author/Authors

    Wendi M. David، نويسنده , , Dalip Kumar، نويسنده , , Sean M. Kerwin، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2000
  • Pages
    4
  • From page
    2509
  • To page
    2512
  • Abstract
    The benzimidazolium salt 2, incorporating an aza-enediyne moiety, has been prepared and is shown to be a very effective DNA-cleavage agent under mild physiological conditions. Its mechanism of action is currently under investigation but may involve the generation of a diradical intermediate, DNA alkylation, or both.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2000
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    791141

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791141