Title of article :
Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator
Author/Authors :
Nobutoshi Murakami، نويسنده , , Masanori Sugimoto، نويسنده , , Mari Morita، نويسنده , , Shin-ichi Akiyama، نويسنده , , Motomasa Kobayashi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
4-Deacetoxyagosterol A was synthesized from ergosterol by utilizing reductive regioselective epoxy cleavage as a key reaction. This synthesized congener of agosterol A, a spongean MDR-modulator, showed similar MDR-modulating activity against KB CV-60 cells overexpressing MRP.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
