Title of article
Arylacetamides as peripherally restricted kappa opioid receptor agonists
Author/Authors
Virendra Kumar Mishra، نويسنده , , Michael A. Marella، نويسنده , , Luz Cortes-Burgos، نويسنده , , An-Chih Chang، نويسنده , , Joel A. Cassel، نويسنده , , Jeffrey D. Daubert، نويسنده , , Robert N. DeHaven، نويسنده , , Diane L. DeHaven-Hudkins، نويسنده , , Susan L. Gottshall، نويسنده , , Erik Mansson، نويسنده , , Alan L. Maycock، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2567
To page
2570
Abstract
Analogues of the kappa (κ) opioid receptor agonist, ICI 199441, were prepared. Ki values for these analogues at the cloned human κ opioid receptor ranged from 0.058 to 25 nM. Trifluoromethylaryl derivatives were potent analgesics when administered subcutaneously in the rat and were more peripherally restricted than the parent compound, ICI 199441.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791155
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