Author/Authors :
Michael Z. Hoemann، نويسنده , , G. Kumaravel، نويسنده , , Roger L. Xie، نويسنده , , Richard F. Rossi، نويسنده , , Sylvia Meyer، نويسنده , , Alban Sidhu، نويسنده , , Gregory D. Cuny، نويسنده , , James R. Hauske، نويسنده ,
Abstract :
A novel structural class of antibacterials, 2-(1H-indol-3-yl)quinolines, effective against methicillin-resistant Staphylococcus aureus (MRSA), was discovered from a combinatorial library. A structure–activity relationship (SAR) study was conducted to determine the pharmacophore and increase the potency of these compounds. Compounds were prepared that had minimum inhibitory concentrations (MICs) <1.0 μg/mL against MRSA and retained activity against two strains of glycopeptide intermediate-resistant S. aureus (GISA).
