Title of article
A novel pyridazinone derivative as a nonprostanoid PGI2 agonist
Author/Authors
Kazunori Tsubaki، نويسنده , , Kiyoshi Taniguchi، نويسنده , , Seiichiro Tabuchi، نويسنده , , Osamu Okitsu، نويسنده , , Kouji Hattori، نويسنده , , Jiro Seki، نويسنده , , Kazuo Sakane، نويسنده , , Hirokazu Tanaka MD، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2787
To page
2790
Abstract
A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 μM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791205
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