Author/Authors :
Brian Walker، نويسنده , , Martin F. Brown، نويسنده , , John F. Lynas، نويسنده , , S. Lorraine Martin، نويسنده , , Andrew McDowell، نويسنده , , Bernard Badet، نويسنده , , Alan J. Hill، نويسنده ,
Abstract :
A series of electrophilic glutamine analogues based on 6-diazo-5-oxo-norleucine has been prepared, using novel synthetic routes, and evaluated as inhibitors of Escherichia coli. glucosamine synthetase. The γ-dimethylsulphonium salt analogue of glutamine was found to be one of the most potent inactivators of this enzyme yet reported, with an apparent second order rate constant (k2/Ki) of 3.5×105 M−1 min−1.
