Title of article
Inhibition of escherichia coli glucosamine synthetase by novel electrophilic analogues of glutamine—comparison with 6-diazo-5-oxo-norleucine
Author/Authors
Brian Walker، نويسنده , , Martin F. Brown، نويسنده , , John F. Lynas، نويسنده , , S. Lorraine Martin، نويسنده , , Andrew McDowell، نويسنده , , Bernard Badet، نويسنده , , Alan J. Hill، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2795
To page
2798
Abstract
A series of electrophilic glutamine analogues based on 6-diazo-5-oxo-norleucine has been prepared, using novel synthetic routes, and evaluated as inhibitors of Escherichia coli. glucosamine synthetase. The γ-dimethylsulphonium salt analogue of glutamine was found to be one of the most potent inactivators of this enzyme yet reported, with an apparent second order rate constant (k2/Ki) of 3.5×105 M−1 min−1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791207
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