Author/Authors :
Dong Jin Kim، نويسنده , , Kyung Jae Seo، نويسنده , , Kyung Seok Lee، نويسنده , , Kye Jung Shin، نويسنده , , Kyung Ho Yoo، نويسنده , , Dong Chan Kim، نويسنده , , Sang Woo Park، نويسنده ,
Abstract :
A new series of 1β-methylcarbapenems 1a–i bearing isoxazoloethenyl groups on the pyrrolidine ring has been prepared and evaluated for in vitro antibacterial activity and stability to DHP-I. Most compounds showed excellent antibacterial activity and high stability to DHP-I superior to that of meropenem. Of these new carbapenems, 1a,b,h exhibited the best combination of antibacterial activity and DHP-I stability.
