Author/Authors :
Nan Zhang، نويسنده , , Biqi Wu، نويسنده , , Dennis Powell، نويسنده , , Allan Wissner، نويسنده , , Middleton B. Floyd، نويسنده , , Eleonora D. Kovacs، نويسنده , , Lourdes Toral-Barza، نويسنده , , Constance Kohler، نويسنده ,
Abstract :
A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50ʹs against MAP kinase kinase, and have potent inhibitory activity in tumor cells.
