Title of article
Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle
Author/Authors
Ying Li، نويسنده , , Feng Shan، نويسنده , , Jin-Ming Wu، نويسنده , , Guang-Shao Wu، نويسنده , , Jian Ding، نويسنده , , Dong Xiao، نويسنده , , Wei-Yi Yang، نويسنده , , Ghanem Atassi، نويسنده , , Stephane Leonce، نويسنده , , Daniel-Henri Caignard، نويسنده , , Pierre Renard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
5
To page
8
Abstract
Modification of artemisinin structure led us to the discovery of a novel class of antitumor compounds. These artemisinin derivatives containing cyano and aryl groups showed potent antiproliferative effect in vitro against P388 and A549 cells. This activity was reflected in P388 murine leukemia by an accumulation of cells in G1 phase, and induction of apoptosis.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791216
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