Title of article
Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines
Author/Authors
Stephen W. Wright، نويسنده , , David L. Hageman، نويسنده , , Lester D. McClure، نويسنده , , Anthony A. Carlo، نويسنده , , Judith L. Treadway، نويسنده , , Alan M. Mathiowetz، نويسنده , , Jane M. Withka، نويسنده , , Paul H. Bauer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
17
To page
21
Abstract
Anilinoquinazolines currently of interest as inhibitors of tyrosine kinases have been found to be allosteric inhibitors of the enzyme fructose 1,6-bisphosphatase. These represent a new approach to inhibition of F16BPase and serve as leads for further drug design. Enzyme inhibition is achieved by binding at an unidentified allosteric site.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791219
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