Author/Authors :
Stephen W. Wright، نويسنده , , David L. Hageman، نويسنده , , Lester D. McClure، نويسنده , , Anthony A. Carlo، نويسنده , , Judith L. Treadway، نويسنده , , Alan M. Mathiowetz، نويسنده , , Jane M. Withka، نويسنده , , Paul H. Bauer، نويسنده ,
Abstract :
Anilinoquinazolines currently of interest as inhibitors of tyrosine kinases have been found to be allosteric inhibitors of the enzyme fructose 1,6-bisphosphatase. These represent a new approach to inhibition of F16BPase and serve as leads for further drug design. Enzyme inhibition is achieved by binding at an unidentified allosteric site.
