Title of article :
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers
Author/Authors :
Nicholas J. Lawrence، نويسنده , , David Rennison، نويسنده , , Meiki Woo، نويسنده , , Alan T. McGown، نويسنده , , John A. Hadfield، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3′,4′,5′-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
