Title of article
Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds
Author/Authors
O. M. Zack Howard، نويسنده , , Hui Fang Dong، نويسنده , , Joost J. Oppenheim، نويسنده , , Shabana Insaf، نويسنده , , Kalpathy C. Santhosh، نويسنده , , Gitendra Paul، نويسنده , , Mark Cushman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
59
To page
62
Abstract
The anti-HIV agent cosalane and several of its analogues inhibited RANTES-induced migration of human monocytes, but they did not inhibit migration induced by MIP1α or MIP1β. RANTES-induced migration of single receptor CCR1-HEK transfectants was also inhibited by the cosalanes. Acetylation of the reactive amino groups of RANTES abrogated the inhibitory activity of cosalane. The data suggest that cosalane and its structural analogues may interfere with the RANTES/CCR1 interaction by binding to RANTES.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791228
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