Author/Authors :
Marion Raoul، نويسنده , , Corinne Schaeffer، نويسنده , , Stephane Leonce، نويسنده , , Alain Pierré، نويسنده , , Ghanem Atassi، نويسنده , , Reynald Hocquemiller، نويسنده , , Guy Lewin، نويسنده ,
Abstract :
Original cytotoxic bisindole alkaloids with a 1,2,3,4-tetrahydroquinoline bridge were synthesized by reductive amination with various anilines. The most cytotoxic compounds display a high and dose-dependent cell cycle effect with accumulation in the G1 phase. Influence of substitution of the starting aniline on the reaction and on cytotoxicity of produced dimers was pointed out.
