Chemoenzymatic synthesis of functionalized cyclohexylglycines and α-methylcyclohexylglycines via Kazmaier–Claisen rearrangement
Author/Authors :
Tomas Hudlicky، نويسنده , , Kofi Oppong، نويسنده , , Caiming Duan، نويسنده , , Charles Stanton، نويسنده , , Matthew J. Laufersweiler، نويسنده , , Michael G. Natchus، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
3
From page :
627
To page :
629
Abstract :
The synthesis of homochiral functionalized cyclohexylglycines and α-methylcyclohexylglycines via chelated Kazmaier–Claisen rearrangement is described. These were shown to be potent scaffolds for the development of MMP inhibitors.
