Title of article
Importance of the C28–C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A
Author/Authors
Valerie A. Frydrychowski، نويسنده , , Rebecca A. Urbanek، نويسنده , , Amy B. Dounay، نويسنده , , Craig J. Forsyth، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
647
To page
649
Abstract
Okadaic acid is a potent inhibitor of select serine/threonine protein phosphatases. The importance of the C28–C38 hydrophobic domain of okadaic acid for inhibition of PP1 and PP2A was investigated. The hydrophobic domain is required but not sufficient for potent inhibition, and it also contributes to differential inhibition between PP1 and PP2A.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791243
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