Title of article
The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
Author/Authors
Helen F. Boyd، نويسنده , , Beverley Hammond، نويسنده , , Deirdre M. B. Hickey، نويسنده , , Robert J. Ife، نويسنده , , Colin A. Leach، نويسنده , , V. Ann Lewis، نويسنده , , Colin H. Macphee، نويسنده , , Kevin J. Milliner، نويسنده , , Ivan L. Pinto، نويسنده , , Stephen A. Smith، نويسنده , , Ian G. Stansfield، نويسنده , , Colin J. Theobald، نويسنده , , Caroline M. Whittaker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
701
To page
704
Abstract
Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase A2, has given inhibitors of nanomolar potency and improved physicochemical properties. Compound 23 was identified as a potent, highly water soluble, CNS penetrant inhibitor suitable for intravenous administration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791255
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